ID 83258
Author
Kamada, masaharu Department of Obstetrics and Gynecology, The University of Tokushima School of Medicine
Maegawa, Masahiko Department of Obstetrics and Gynecology, The University of Tokushima School of Medicine
Yan, Yuan-chang Shanghai Institute of Cell Biology, Academia Sinica
Koide, Samuel S. Center for Biomedical Research, The Population Council
Aono, Toshihiro Department of Obstetrics and Gynecology, The University of Tokushima School of Medicine
Keywords
antisperm antibody
infertility
contraception
immunoglobulin binding factor
sperm antigen
Content Type
Journal Article
Description
Antisperm antibodies can cause infertility by interacting with spermatozoa through immunoglobulin binding protein thereby blocking their penetrance of cervical mucus and / or by interfering with sperm-egg interaction. However, these antibodies appear not to be cytotoxic to embryos since a high implantation rate and consequently high pregnancy rate were achieved by IVF-ET treatment of women with antisperm antibodies. Also the finding that these antibodies do not appear to cause any deleterious clinical symptoms and have yet be associated with infertility suggested that sperm antigens are promising candidates in the development of immunocontraceptives. Some synthetic peptides corresponding to segments of human sperm antigens have effectively induced infertility in female rats when administered as an immunogen. Different peptides, adjuvants and routes of administration should be studied to determine the optimum conditions for inducing high antisperm antibody titers in the host. Moreover, identification of various steps and factors that are involved in regulating the production of antisperm antibodies such as immunoglobulin binding factor may open new paths in the treatment of immunological infertility and at the same time lead to a more effective immunocontraceptive.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
46
Issue
1-2
Start Page
19
End Page
28
Sort Key
19
Published Date
1999
Remark
FullText File
language
eng