ID 83261
Author
Iida, Shinya Department of Virology, The University of Tokushima School of Medicine
Fukumori, Tomoharu Department of Virology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oshima, Yoko Department of Virology, The University of Tokushima School of Medicine
Koyama, A.Hajime Department of Virology, The University of Tokushima School of Medicine
Adachi, Akio Department of Virology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
HIV-1
Vpu
accessory gene
Content Type
Journal Article
Description
A mutant designated NL-E65, which lacks the expression of entire vpu gene, was constructed from T-cell tropic wild-type (wt) human immunodeficiency virus type1(HIV-1) clone and monitored for its replication property in human cells, along with a mutant NL-Ss which expresses a C-terminal truncated Vpu. The mutant NL-Ss could grow in two cell lines and in all peripheral blood mononuclear cell (PBMC) preparations to some extent, with kinetics similar to those of wt virus. Likewise, the mutant NL-E65exhibited a replication property typical to the vpu mutant in the two cell lines and in all PBMC cultures, growing at a low level. Along with the results previously reported, these data indicate that HIV-1 Vpu is dispensable for virus replication in any of the types of cells so far tested.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
46
Issue
1-2
Start Page
43
End Page
47
Sort Key
43
Published Date
1999
Remark
EDB ID
FullText File
language
eng
departments
University Hospital
Medical Sciences