ID 83265
Author
Zhu, Chun-Sheng Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Ohsaki, Katsuichiro Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Ii, Kunio First Department of Pathology, The University of Tokushima School of Medicine
Ye, Qing First Department of Pathology, The University of Tokushima School of Medicine
Tran, Yen Hai Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Ohba, Yasuo Department of Orthodontics, The University of Tokushima School of Dentistry
Moriyama, Keiji Department of Orthodontics, The University of Tokushima School of Dentistry
Keywords
aluminum oxide
long-term implantation
subcutaneous tissue reaction
histology
rats
Content Type
Journal Article
Description
To evaluate biocompatibility to tissue in long-term implantation, Bioceram® discs made of aluminum oxide (Al2O3) were implanted subcutaneously within the interscapular region of 64 rats for six to 20 months. Histological sections stained with haematoxylin and eosin (H&E) and the surface of the implant material were observed using light micros-copy. Different cell types and the thickness of fibrous capsules surrounding the implants were examined quantitatively by light microscopy. Small numbers of macrophages (2.8±0.7%) and lymphocytes (2.7±0.9%) were observed at six months after implantation, gradually decreasing to zero at 16, 18 and 20 months. Neither neutrophils nor foreign body giant cells were seen in any specimens. The thickness of fibrous capsules surrounding the implants was closely related to the shape of the implant, but there was no significant change between six and 20 months after implantation. No change in Bioceram® surfaces were observed under stereoscopic microscopy from six to20months after implantation. The study results indicate that Bioceram® is a satisfactory biocompatible material for reconstructive surgery from the viewpoint of long-term tissue response. Present results of experiments with Bioceram® are also compared to previous results with Apaceram® and different tissue responses of the two materials are discussed.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
46
Issue
1-2
Start Page
97
End Page
103
Sort Key
97
Published Date
1999
Remark
EDB ID
FullText File
language
eng