ID 83490
Author
Hashimoto, Ichiro Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakanishi, Hideki Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shono, Yoshitaka Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine
Tanaka, Shinji Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine
Keywords
rabbit ear chamber
desferrioxamine
thrombus formation
microcirculation
Content Type
Journal Article
Description
We investigated the effects of the iron chelator desferrioxamine (DFX) on thrombus formation in the arterioles and venules of the rabbit ear chamber. Thrombi were induced by irradiation with filtered light in combination with a fluorescent dye. The occlusive thrombus formation time was significantly extended by DFX. The mor-phological composition of thrombi in the arterioles and venules was different. In the arterioles, the thrombi consisted of platelet aggregation, but in the venules, platelets and leukocytes accumulated on the endothelium. This suggests that hydroxyl radicals may be important mediators in this model, as DFX is known as a hydroxyl radical scav-enger. Furthermore, the components of thrombi in the arterioles and venules in the skin microvascular system may be different.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
46
Issue
3-4
Start Page
200
End Page
204
Sort Key
200
Published Date
1999
Remark
EDB ID
FullText File
language
eng
departments
Medical Sciences