ID 83493
Author
Iwano, Junko Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
Nakamura, Yoichi Third Department of Internal Medicine, The University of Tokushima School of Medicine
Izumida, Takashi Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
Yokota, Masayuki Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences
Takiguchi, Yoshiharu Department of Clinical Pharmacology, The University of Tokushima Faculty of Pharmaceutical Sciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Minakuchi, Kazuo Division of Pharmacy, University Hospital, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sone, Saburo Third Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
theophylline
creatine kinase
drug interaction
Content Type
Journal Article
Description
An increase in the serum creatine kinase (CK) level is one of the side effects of theophylline;on rare occasions, the increase may be followed by rhabdomyolysis. Theophylline is often administered with drugs that potentially elevate the serum CK level (CK-elevating drugs) such as β-agonists and steroids. However, the effects of the combined treatment of theophylline and CK-elevating drugs have not been reported. We, therefore, retrospectively investigated the effects of combined treatment on the serum CK level, in391asthmatic outpatients.
In this study, the number and type of the CK-elevating drugs administered, and the serum levels of CK and theophylline, were investigated. The patients were divided into four groups:the theophylline-treated and CK-elevating drug-treated group, the theophylline-treated and non-CK-elevating drug-treated group, the non-theophylline-treated and CK-elevating drug-treated group, and the non-theophylline-treated and non-CK-elevating drug-treated group.
The theophylline-treated and CK-elevating drug-treated group showed about 100%higher serum CK levels (225IU/L) than any other group (102-124IU/L), and no increase in the serum theophylline level. This result indicates that there is a synergistic effect of theophylline and CK-elevating drugs on the serum CK level.
The combined treatment of theophylline and CK-elevating drugs induces a synergistic increase in the serum CK level, indicating not pharmacokinetic but pharmacodynamic interactions with these drugs.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
47
Issue
1-2
Start Page
9
End Page
13
Sort Key
9
Published Date
2000
Remark
FullText File
language
eng
departments
Pharmaceutical Sciences
Medical Sciences