ID 83622
Author
Miyamoto, Ken-ichi Department of Nutritional Science, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ito, Mikiko Department of Nutritional Science, The University of Tokushima School of Medicine
Segawa, Hiroko Department of Nutritional Science, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuwahata, Masashi Department of Nutritional Science, The University of Tokushima School of Medicine
Keywords
parathyroid
phosphate
transporter
secondary hyperparathyroidism
vitamin D
Content Type
Journal Article
Description
Retention of inorganic phosphate (Pi) and associated hyperphosphatemia are important in the development of hyperparathyroidism secondary to renal failure. The beneficial effect of a low-Pi diet in the prevention of hyperparathyroidism can be attributed to the decrease in PTH secretion. This effect of Pi may be mediated by specific molecules in the parathyroid cell membrane. A complementary DNA encoding a Na+-Pi co-transporter, termed rat PiT-1, has been isolated from rat parathyroid. The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion. The parathyroid Pi transporter may mediate the effects of extracellular Pi and PTH secretion in secondary hyperparathyroidism. In this study, we focus on the function of Na/Pi co-transporters in the parathyroid glands as inorganic Pi sensor.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
47
Issue
3-4
Start Page
118
End Page
122
Sort Key
118
Published Date
2000
Remark
FullText File
language
eng
departments
Medical Sciences