ID 83625
Author
Sakamoto, Sadaichi Department of Nutrition, The University of Tokushima School of Medicine
Muto, Takeshi Department of Nutrition, The University of Tokushima School of Medicine
Yokota, Masashi Department of Nutrition, The University of Tokushima School of Medicine
Ishimura, Noriko Department of Nutrition, The University of Tokushima School of Medicine
Niwa, Yasuharu Department of Nutrition, The University of Tokushima School of Medicine
Harada, Nagakatsu Department of Nutrition, The University of Tokushima School of Medicine KAKEN Search Researchers
Okada, Kazuko Department of Nutrition, The University of Tokushima School of Medicine
Nakaya, Yutaka Department of Nutrition, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
hyperinsulinemic euglycemic clamp
insulin resistance
dietary fat
training
food restriction
Content Type
Journal Article
Description
High-fat diets induce whole-body insulin resistance. The aim of this study was to compare the effect of two interventions:3-day food restriction (66%of ad libitum fed) and 3-day exercise training (voluntary running wheels), on decreased insulin-mediated whole body glucose uptake in high-fat fed rats (5 mo old) using the hyperinsulinemic euglycemic clamp procedure. The control group was maintained on rat chow alone. After high-fat feeding for2wk, insulin-stimulated whole body glucose utilization was significantly decreased by26%. The exercise training was more effective than food restriction in lowering plasma concentrations of insulin and triacylglycerol and tissue concentrations of triacylglycerol in soleus muscles. Diminished whole-body glucose uptake resulting from high-fat feeding was reversed completely by exercise training, but only partially by food restriction.
The time course of starvation on insulin-stimulated glucose uptake was also observed in high-fat fed rats. Although the extension of starvation time to 48h resulted in decreased plasma glucose, insulin and triacylglycerol concentrations, whole body glucose uptake did not increase further.
These findings suggest that short-term exercise has a higher restorative effect on insulin sensitivity in high-fat fed rats than food restriction, in spite of the same loss in body weight, presumably due in part to improved local lipid availability.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
47
Issue
3-4
Start Page
138
End Page
144
Sort Key
138
Published Date
2000
Remark
FullText File
language
eng
departments
Medical Sciences