ID 83629
Author
Doi, Toshio Department of Laboratory Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
mesangial cell
proliferation
Gas 6
growth factor
vitamin D analog
Content Type
Journal Article
Description
Mesangial cell proliferation is a general characteristic of a variety of glomerular diseases. Therefore, an understanding of the regulatory mechanism is important for treatment of glomerular diseases. The present review shows that the growth arrest gene 6 (Gas 6) is a new autocrine growth factor of mesangial cells and that warfarin inhibits mesangial cell proliferation by inhibiting the γ-carboxylation of Gas 6 in vitro and in vivo. The present findings also show that a vitamin D analog (22-oxa-calcitriol) is a new growth regulator of mesangial cells in vitro and in vivo. These findings indicate that these compounds have considerable potential for therapeutic use in the treatment of progressive glomerular disease.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
48
Issue
1-2
Start Page
1
End Page
4
Sort Key
1
Remark
FullText File
language
eng
departments
Medical Sciences