ID 83833
Author
Batmunkh, Rentsenkhand Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
Nishioka, Yasuhiko Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Aono, Yoshinori Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN Search Researchers
Azuma, Momoyo Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kinoshita, Katsuhiro Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN Search Researchers
Kishi, Jun Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN Search Researchers
Makino, Hideki Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
Kishi, Masami Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
Takezaki, Akio Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
Sone, Saburo Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
CCN
integrin
proliferation
fibroblasts
focal adhesion kinas
Content Type
Journal Article
Description
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin β1, leading to the phosphorylation of FAKY397. Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
3-4
Start Page
188
End Page
196
Sort Key
188
Published Date
2011
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital