ID 83837
Author
Nemoto, Hideyuki Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School|Genmai Koso Co., Ltd.
Ikata, Kazue Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
Arimochi, Hideki Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Iwasaki, Teruaki Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
Ohnishi, Yoshinari Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Kuwahara, Tomomi Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
Kataoka, Keiko Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
dietary fiber
fermented brown rice and rice bran
intestinal microbiota
organic acid
randomized controlled trial
Content Type
Journal Article
Description
Purpose : The aim of this study is to investigate the prebiotic effects of brown
rice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro and
in healthy adults. Methods : Fresh fecal slurries from six healthy adults were incubated
with FBRA to confirm prebiotic potentials of FBRA. Another thirty-six healthy adults
were randomly allocated to 2 groups for the clinical study. Subjects consumed 21.0 g/day
of either FBRA or control food for 2 weeks, followed by a 12-week intermission and then
2-week ingestion vice versa. Main outcome measures were bifidobacterial numbers and
organic acid concentration in feces. Sub outcome measures were fecal microbiota, fecal
environments and bowel function. Results : Incubation of fecal slurries with FBRA in
vitro resulted in increased organic acids with individual-specific patterns. Bifidobacterial
numbers were increased during incubation. In the clinical study, all participants
safely completed this study. FBRA had little effect on fecal number of bifidobacteria, concentrations
of organic acids or putrefactive metabolites, fecal pH, or fecal microbiota.
Conclusion : FBRA has the potentials as a prebiotic, however, we could not detect its
effects on the intestinal environment in vivo. The results in a clinical study indicated that
FBRA could be safely used for healthy adults.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
3-4
Start Page
235
End Page
245
Sort Key
235
Published Date
2011-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
departments
Medical Sciences