ID 83934
Author
Kurita, Nobuhiro Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Shimada, Mitsuo Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Iwata, Takashi Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nishioka, Masanori Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
Morimoto, Shinya Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
Yoshikawa, Kozo Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Higashijima, Jun Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Miyatani, Tomohiko Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Nakao, Toshihiro Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Keywords
In intraperitoneal infusion of PTX with S-1
DLT was leukocytopenia
MTD and RD were PTX 90 mg/m2, 80 mg/m2, respectively.
These findings were supported by pharmocokinetics of PTX
Content Type
Journal Article
Description
Background : Intraperitoneal administration of taxanes revealed excellent anti-tumor effect for peritoneal metastasis of gastric cancer in some experimental models. The aim of this study is to determine maximum tolerated dose (MTD), dose limiting toxicity (DLT) and recommended dose (RD) of intraperitoneally infused paclitaxel (PTX) with S-1 as a phase I study. Patients and Methods : Eighteen patients with advanced gastric cancer in addition to confirmed peritoneal metastasis using laparoscopy were enrolled in this study. The regimen consists of oral administration of S-1 (Dose 80mg : BSA<1.25 m2, 100 mg : 1.25<BSA<1.5 m2, 120 mg : BSA>1.5 m2) for 14 days and intraperitoneal infusion of PTX (Dose escalation : level I : 40, II : 60, III : 80, level IV : 90, V : 100 mg/m2) at day1 and 14. PTX concentrations in serum and ascites were determined at 4, 8, 12, 24, 48 hours after the infusion, which was repeated twice every 4 weeks. Results : The number of patients were as follows : Level I : 3, Level II : 6, Level III : 3, Level IV : 3, Level V : 3. Grade 3 leukocytopenia was confirmed in 1 (Level II) and 2 (Level V). MTD is 90 mg/m2, RD is 80 mg/m2 and DLT is Grade 3 leukocytopenia. The average serum PTX concentrations remained in optimal range except for all 3 of level V patients. In all cohorts, the PTX concentrations in the ascites were approximately 1000 folds higher than those in serum for 48 hours after the infusion. Conclusions : MTD and RD were PTX 90 mg/m2, 80 mg/m2, respectively. These findings were supported by pharmocokinetics of PTX
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
1-2
Start Page
134
End Page
139
Sort Key
134
Published Date
2011-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
Liberal Arts and Sciences
University Hospital