ID 83937
Author
Shimohata, Takaaki Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takahashi, Akira Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Vibrio parahaemolyticus
diarrhea
TDH
TRH
T3SS
Content Type
Journal Article
Description
Vibrio parahaemolyticus is a human pathogen that naturally inhabits marine
and estuarine environments. Infection with V. parahaemolyticus is often associated with
the consumption of raw or undercooked seafood, causing gastroenteritis with watery diarrhea.
The presence of two type III secretion system (T3SS) proteins, thermostable direct
hemolysin (TDH) and TDH-related hemolysin (TRH), has been closely associated with the
severity of diarrheal illness. TDH and TRH have various biological activities including
hemolytic activity, cardiotoxicity, and enterotoxicity. T3SS1 is involved in cytotoxicity
to host cells and orchestrates a multifaceted host cell infection by induction of autophagy,
cell rounding, and cell lysis. T3SS2 is thought to be related to the enterotoxicity
of V. parahaemolyticus. The activities of inducing diarrhea of each of the virulence factors
were summarized in this review.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
179
End Page
182
Sort Key
179
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng
departments
Medical Sciences