ID 83939
Author
Nakatani, Hajime Department of Surgery, Kubokawa Hospital, Shimanto-cho
Akimori, Toyokazu Department of General Surgery, Hatakenmin Hospital, Sukumo
Takezaki, Yuka Department of Surgery, Kochi Medical School, Kochi University
Hanazaki, Kazuhiro Department of Surgery, Kochi Medical School, Kochi University
Keywords
esophagus
so-called carcinosarcoma
vascular endothelial growth factor
vascular endothelial growth factor receptor
Content Type
Journal Article
Description
Human carcinosarcomas of esophagus are uncommon malignant neoplasms that
are composed both carcinomatous and sarcomatous components. We established a novel
cell line, HN-Eso-1, from the metastatic esophageal spindle cell carcinoma (so-called carcinosarcoma).
In this study, we estimated the vascular endothelial growth factors (VEGFs)
and VEGF receptors (VEGFRs). Reverse transcription polymerase chain reaction (RTPCR)
studies revealed that VEGF-A,-C,-D and VEGFR-1,-2 were upregulated. Cisplatin
reduced the cell viability of HN-Eso-1 cells and VEGF attenuated its effect. These results
suggest that expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-1, and VEGFR-2 are involved
in the cell’s autocrine system and that VEGF protected these cells from the antitumor
agent.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
232
End Page
236
Sort Key
232
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng