ID 83941
Author
Watanabe, Masanari Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Sano, Hiroyuki Department of Respiratory Medicine and Allegology, School of Medicine
Tomita, Katsuyuki Department of Respiratory Medicine and Allegology, School of Medicine
Yamasaki, Akira Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Kurai, Jun Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Hasegawa, Yasuyuki Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Igishi, Tadashi Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Okazaki, Ryota Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Tohda, Yuji Department of Respiratory Medicine and Allegology, School of Medicine
Burioka, Naoto Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Shimizu, Eiji Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University
Keywords
airway responsiveness
asthma
circadian rhythm
gastroesophageal reflux
salivary pH
Content Type
Journal Article
Description
Salivary pH is associated with esophageal acid reflux and neutralization of
esophageal acid. In this study, we assessed the association between nocturnal decline of
salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients
with mild asthma (7 men and 2 women ;mean age 33.3 years ;mean %predicted
FEV1.0 89.4%) and 10 healthy volunteers (6 men and 4 women ; mean age 31.2 years) using
a pH indicator tape. The buffering capacity of saliva was defined as the median effective
dose (ED50) for acidification of saliva with 0.01 N HCl, and airway responsiveness was
defined as the dose of methacholine producing a 35% fall in Grs (PD35-Grs). There was a
significant correlation between the values obtained from the pH indicator tape and those
obtained from the electrometric pH meter. Using the indicator tape for sequential monitoring,
we observed a nocturnal fall (pH) in salivary pH in all subjects. A significant correlation
was found between airway hyperresponsiveness (PD35-Grs) and eitherpH or ED50
in mildly asthmatic patients. Vagal reflux dysfunction might contribute to nocturnal
salivary pH as well as to airway hyperresponsiveness in mild asthmatics.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
260
End Page
269
Sort Key
260
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng