ID 83943
Author
Tsujikawa, Tetsuya Department of Radiology, University of Fukui
Kamibayashi, Tomohito Department of Radiology, University of Fukui
Tsuchida, Tatsuro Department of Radiology, University of Fukui
Ohkoshi, Yusuke Department of Radiology, University of Fukui
Kimura, Hirohiko Department of Radiology, University of Fukui
Keywords
bone SPECT
MRI
fusion
functional and anatomic images
Content Type
Journal Article
Description
We recently experienced a case of cerebral infarction incidentally found by
whole body bone scintigraphy for the detection of bone metastasis from renal cell carcinoma.
Additional bone SPECT and brain MR fusion images clearly demonstrated the
wedge-shaped uptake of tracer corresponded to the abnormal intensity reflecting subacute
cerebral infarction. Follow-up bone scan and fused images with MRI showed complete
resolution of the abnormal uptake in chronic phase. A breakdown in the normal
blood-brain barrier results in abnormal ionic calcium flux into the cells following altered
cell membrane integrity leading to precipitation of calcium salts which eventually binds
to bone imaging tracer such as 99mTc-methylene diphosphonate. That is, increased accumulation
of bone seeking agents represents lethal cell death. The recent development of
software and hardware has enabled the fusion of functional and anatomic images. Image
fusion between SPECT with various tracers and MRI is expected to provide clues as
to the underlying cause of diseases and to decide our treatment planning in the near
future.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
334
End Page
337
Sort Key
334
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng