ID 83945
Author
Kishmoto, Miyako Department of Diabetes and Metabolic Medicine,National Center for Global Health and Medicine
Endo, Hisako Department of Diagnostic Pathology,National Center for Global Health and Medicine
Hagiwara, Shotaro Division of Hematology National Center for Global Health and Medicine
Miwa, Akiyoshi Division of Hematology National Center for Global Health and Medicine
Noda, Mitsuhiko Department of Diabetes and Metabolic Medicine,National Center for Global Health and Medicine
Keywords
hemochromatosis
iron overload
pancreatic islets
diabetes
immunohistochemical analysis
Content Type
Journal Article
Description
Excessive iron storage sometimes causes diabetes in patients with hemochromatosis,
a disease caused by iron overloading. We performed an immunohistochemical
analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused
by frequent blood transfusions, and extensive hemosiderin deposition was observed in
the liver and pancreas. The pancreatic islets of the patient and a control subject were
stained to detect glucagon, insulin, and proinsulin. Significantly lower levels of immunoreactivity
with both insulin antibodies and proinsulin antibodies, but not with glucagon
antibodies, was observed in the islet cells in the patient’s tissue than in the islet cells of
the control. Hemosiderin deposition in the islets is known to be exclusively distributed
in the β-cells, thus, selective iron-induced damage to the β-cells may have affected insulin
synthesis and secretion and led to glucose intolerance in the patient.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
345
End Page
349
Sort Key
345
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng