ID 84160
Title Transcription
Sivelestat Sodium Hydrate ト エンドトキシン キュウチャク リョウホウ トノ ヘイヨウ リョウホウ ガ ユウヨウ デ アッタ ARDS ノ イチレイ
Title Alternative
A case of acute respiratory distress syndrome (ARDS) due to perforation of the sigmoid colon : effective therapy with sivelestat sodium hydrate (Elaspol) and polymyxin-B immobilized direct hemoperfusion (PMX-DHP)
Author
Kaneda, Yuji Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Yada, Seigo Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Yamaguchi, Takeshi Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Miyauchi, Takayuki Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Kuratate, Masashi Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Yogita, Shiro Department of Surgery, Tokushima Prefectural Miyoshi Hospital
Keywords
sivelestat sodium hydrate
elaspol
PMX-DHP
ARDS
perforation of colon
Content Type
Journal Article
Description
We report here a case of Acute Respiratory Distress Syndrome(ARDS)due to perforation of the sigmoid colon, for which therapy with Sivelestat Sodium Hydrate(SSH, Elaspol)and Polymyxin B-immobilized Direct Hemoperfusion(PMX-DHP)was shown to be effective. An 88-yearold woman was admitted to our hospital because of abdominal pain. Abdominal computed tomography showed free air present in the liver and near the sigmoid colon. These results suggested sigmoid colon perforation, and we performed Hartmann’s operation and drainage. After operation, her blood pressures and the PaO2/FiO2 ratio decreased. The patient was then diagnosed septic shock and ARDS ; and PMX-DHP was performed, followed by the initiation of SSH administration. After therapy, she showed improvements in her conditions of septic shock and ARDS. It is inferred that therapy with PMX-DHP and SSH is effective for ARDS in view of an observed two-fold suppression in vascular endothelial cell damage.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Volume
63
Issue
1-2
Start Page
54
End Page
57
Sort Key
54
Published Date
2007-04-25
Remark
FullText File
language
jpn