ID 84289
Author
Abe, Akiko Department of Obstetrics and Gynecology, Oe Kyodo Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ikawa, Hiroshi Department of Obstetrics and Gynecology, Oe Kyodo Hospital
Ikawa, Saki Department of Obstetrics and Gynecology, Oe Kyodo Hospital
Keywords
desensitization
hypersensitivity reactions
carboplatin
cisplatin
Content Type
Journal Article
Description
Platinum-based chemotherapy is the standard regimen for the treatment of gynecologic
cancers ; however, hypersensitivity reactions (HR) to platinum often lead to discontinuation
of this effective treatment. Here we performed a desensitization protocol
for platinum infusion in 3 patients who required platinum re-administration after developing
HR. Two patients (Case 1 and 2) were treated with the desensitization protocol
successfully without developing HR during the subsequent 3 courses. Case 3 tolerated
desensitization well for 2 courses, but in the 3rd course, she developed severe HR immediately
after the initiation of cisplatin infusion because the desensitization protocol was
unintentionally omitted. These cases show the usefulness and effectiveness of the desensitization
protocol for the continuation of platinum treatment in patients who have undergone
an extended number of treatments.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
1-2
Start Page
163
End Page
167
Sort Key
163
Published Date
2010-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng
departments
Medical Sciences