マッキ ジンフゼン トウニョウビョウ カンジャ ニオケル ケットウ カンリ シヒョウ : HbA1c ノ モンダイテン
An index of glycemic control in diabetic patients with end-stage renal disease : validity of HbA1c value
Chujo, Keiko Department of Clinical Laboratory, Kawashima Hospital
Okada, Kazumi Department of Clinical Laboratory, Kawashima Hospital
Yamada, Mayumi Department of Clinical Laboratory, Kawashima Hospital
Oohashi, Teruyo Department of Clinical Laboratory, Kawashima Hospital
Komatu, Machiko Department of Internal Medicine, Kawashima Hospital
Shima, Kenji Department of Internal Medicine, Kawashima Hospital
Mizuguchi, Takashi Department of Internal Medicine, Kamojima Kawashima Clinic
We have investigated the validity of HbA1c values measured as the index of glycemic controls in diabetics with end-stage renal disease（ESRD）. HbA1c levels for diabetics with ESRD undergoing haemodialysis were lower than indicated by their blood glucose control. However, the changes in glycated albumin in relation to the blood glucose control in the dialysis patients matched those in diabetics without renal dysfunction.
Diabetics with stage４or５chronic kidney disease（CKD）not on haemodialysis had significantly lower values of HbA1c and shorter RBC lifespan compared with patients without renal dysfunction. When assessing blood glucose control based solely on HbA1c, erroneous result may be obtained in diabetics with ESRD.
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