ID 98233
Title Transcription
コウウンドウセイ モデル ラット SPORTS ノ カイバ ニオケル ノルエピネフリン ドウタイ ト ジハツ ウンドウリョウ
Title Alternative
Hippocampal norepinephrine level and exercise behavior in SPORTS rats
Author
Morishima, Masaki Department of Nutrition and Metabolism, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Hara, Sayuri Department of Nutrition and Metabolism, The University of Tokushima Graduate School
Harada, Nagakatsu Department of Nutrition and Metabolism, The University of Tokushima Graduate School KAKEN Search Researchers
Sano, Atsuko Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
Seno, Hiromasa Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
Takahashi, Akira Department of Nutrition and Metabolism, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakaya, Yutaka Department of Nutrition and Metabolism, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
exercise behavior
hyper-running
monoamine oxidase A
norepinephrine
hippocampus
Content Type
Journal Article
Description
Reduced physical exercise activity contributes to the development of several metabolic disorders including obesity, type 2 diabetes and hypertension. Especially in the developed countries, many people choose not to be active physically, possibly because of a reduced motivation to participate in exercise activities. Thus, augmentation of exercise motivation and subsequent increase in the physical activity would reduce an incidence of these metabolic disorders. In order to clarify the psychological mechanisms responsible for an increased exercise activity, we have generated and established a line of SPORTS (Spontaneously-Running-Tokushima-Shikoku) rat for high levels of voluntary wheel running. Male SPORTS rats run voluntarily in the running wheel almost six times longer than control Wistar rats. Here we examined the relation of the running activity of SPORTS rat with the hippocampal norepinephrine (NE) system including the levels of NE, adrenergic receptors, and degradation enzymes for monoamines. In the hippocampus of SPORTS rats, the level of NE in extracellular fluid was augmented, whereas the level in the homogenate of the whole tissue was decreased even for sedentary conditions. The level of striatal dopamine has not altered in both groups. The protein expression and the activity levels of monoamine oxidase A (MAOA), a critical enzyme for the degaradation of NE, were decreased in the hippocampus of SPORTS rats to increase extracellular NE level. Thus, inhibition of oxidase activity in normal Wistar rats markedly increased wheel running activity. Our results indicate that the hippocampal NE determines the neural basis of the psychological regulation of exercise behavior in SPORTS rats. Modulation of NE transmission in the hippocampus will be a good method for enhancing the exercise behavior both in clinical patients and in healthy humans.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
61
Issue
5-6
Start Page
185
End Page
188
Sort Key
185
Published Date
2005-12-20
Remark
EDB ID
FullText File
language
jpn
departments
Medical Sciences