| ID | 115991 |
| Title Alternative | 5-アミノレブリン酸を用いた光線力学療法増感剤としてのTX-816及びその誘導体の開発
|
| Author |
篠原, 侑成
Tokushima University
|
| Keywords | 5-Aminolevulinic acid
Protoporphyrin IX
Photodynamic therapy
Schiff base
|
| Content Type |
Thesis or Dissertation
|
| Description | 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic therapy (ALA-PDT) of various cancers. Recently, I found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer.
|
| Published Date | 2021-03-23
|
| Remark | 内容要旨・審査要旨・論文本文の公開
|
| FullText File | |
| language |
eng
|
| TextVersion |
ETD
|
| MEXT report number | 甲第3514号
|
| Diploma Number | 甲先第394号
|
| Granted Date | 2021-03-23
|
| Degree Name |
Doctor of Engineering
|
| Grantor |
Tokushima University
|
