ID 110158
Author
Mukai, Rie Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Horikawa, Hitomi Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School
Fujikura, Yutaka Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School
Kawamura, Tomoyuki Department of Pharmaceutical Chemistry, Institute of Health Biosciences, University of Tokushima Graduate School
Nemoto, Hisao Department of Pharmaceutical Chemistry, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nikawa, Takeshi Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Terao, Junji Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Content Type
Journal Article
Description
Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.
Journal Title
PLOS ONE
ISSN
19326203
Volume
7
Issue
9
Start Page
e45048
Sort Key
45048
Published Date
2012-09-19
Remark
Copyright:© 2012 Mukai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry
Pharmaceutical Sciences
Medical Sciences