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ID 114361
Author
Iwahana, Hiroyuki The University of Tokushima
Fukuda, Ayumi The University of Tokushima
Katsuragi, Kiyonori Otsuka Assay Laboratories
Kinoshita, Moritoshi Otsuka Assay Laboratories
Saito, Shiro The University of Tokushima
Keywords
ras Gene
Missense mutation
Thyroid follicular adenoma
Pheochromocytoma
Content Type
Journal Article
Description
To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis. Mutations of the H‐, K‐, N‐ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained mutated N‐ras codon 61, and one contained the mutated H‐ras codon 61. One of the 19 pheochromocytomas revealed mutation of the H‐ras codon 13. No mutations of the ras gene were detected in pituitary adenomas, parathyroid tumors, thyroid cancers, endocrine pancreatic tumors, and adrenocortical tumors. Based on these findings we conclude that activation of the ras gene may play a role in the tumorigenesis of a limited number of thyroid follicular adenomas and pheochromocytomas, and that mutation of the ras gene is not frequent in other human endocrine tumors.
Journal Title
Japanese Journal of Cancer Research
NCID
AA00690844
Publisher
Japanese Cancer Association|John Wiley & Sons
Volume
83
Issue
10
Start Page
1057
End Page
1062
Published Date
1992-10
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Medical Sciences
Institute of Advanced Medical Sciences