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ID 112032
Title Alternative
画像強調内視鏡を用いたaberrant crypt fociの観察
Author
Kagemoto, Kaizo Tokushima University
Takaoka, Toshi Tokushima University
Keywords
ACF
NBI
BLI
IEE
Colorectal cancer
Content Type
Thesis or Dissertation
Description
Background and study aims Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF.
Patients and methods Patients with a history of colorectal neoplasm were eligible. The number of ACF in the lower rectum was counted first using IEE magnification with narrow- band imaging (NBI) or blue-laser imaging (BLI), and subsequently using the methylene blue method. The primary endpoint was the ACF detection rate with IEE, i. e., the number of ACF detected with IEE relative to the number of ACF detected with methylene blue. The secondary endpoints were bowel preparation time, ACF detection time, and the detection rate with NBI or BLI.
Results A total of 40 patients were enrolled (NBI 20 and BLI 20). The overall detection rate for ACF with IEE was 81.7% (503/616; 95%CI 78.8 – 84.6%), meeting the primary endpoint. The detection rate for ACF with BLI (84.9 %, 258/304) was significantly higher than with NBI (78.5%, 245/312; P < 0.05). Both bowel preparation time and ACF detection time were significantly shorter with IEE versus the methylene blue method (P < 0.01, respectively). The detection rates for dysplastic and non-dysplastic ACF with IEE were 84.4% (27/32) and 80.3% (469/584), respectively.
Conclusion IEE is able to detect ACF during colonoscopy with sensitivity non-inferior to that of the conventional methylene blue method. IEE is simpler than the methylene blue method and is therefore a potentially useful new tool for ACF detection.
Journal Title
Endoscopy International Open
ISSN
21969736
Publisher
Georg Thieme Verlag KG Stuttgart
Volume
6
Issue
8
Start Page
E924
End Page
E933
Published Date
2018-08-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kaizo Kagemotoの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
©2018 Georg Thieme Verlag KG Stuttgart · New York
This article under License of Creative Commons Attribution 4.0 License. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3203号
Diploma Number
甲医第1378号
Granted Date
2018-07-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences