Prion Protein as a Modulator of Influenza
Sakaguchi, Suehiro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Chida, Junji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Worldwide spread of influenza A virus (IAV) strains, which are resistant to currently available anti-influenza agents such as viral neuraminidase inhibitors, has encouraged identification of new target molecules for anti-influenza agents. Reactive oxygen species (ROS) causing oxidative stress play a pivotal role in the pathogenesis of lung injuries induced by infection with IAVs, therefore suggesting that anti-oxidative therapeutics targeting cellular molecules could be beneficial against IAV infection without inducing drug-resistant IAV strains. We recently found that the normal cellular prion protein, PrPC, whose conformational conversion into the amyloidogenic isoform, PrPSc, in the brain is a key pathogenic event in prion diseases, is expressed by lung epithelial cells and exerts a protective role against IAV infection in mice by reducing ROS in infected lungs. The Cu content and activity of anti- oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, were lower in the lungs of PrPC-knockout mice, suggesting that the anti-oxidative activity of PrPC is probably attributable to its function of activating SOD1 through regulating Cu content in lungs. Here, we introduce PrPC as a novel modulator of influenza and its potential implication for anti-oxidative therapies for IAV infection. We also introduce other candidate targets reported for anti- oxidative anti-influenza therapies.
Current Issues in Molecular Biology
Caister Academic Press
This article is published under the Creative Commons Attribution Licence(https://creativecommons.org/licenses/by/4.0/).
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Institute of Advanced Medical Sciences