Electromechanical Coupling in HHD
Saito, Yuko Tokushima University
Yamada, Hirotsugu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kusunose, Kenya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Saito, Ken Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sata, Masataka Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
diastolic electromechanical coupling
Thesis or Dissertation
Background: There is a need to stratify patients who may develop heart failure because of the current “heart failure pandemic”. We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure.
Methods: We measured the time from the peak to end of the T-wave (TpTe) as an electrophysiological parameter, and peak early-diastolic mitral flow (E) and lateral annular (e’) velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis was evaluated.
Results: The e’ was inversely correlated with TpTe (p<0.001) and QTc (p < 0.014), whereas E/e’ was positively correlated with TpTe (p<0.001) and QTc (p<0.001). The TpTe predicted patients with E/e’ > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meir analysis showed that outcome was worse (p=0.003) in patients with higher E/e’ than lower E/e’, however, there was no difference between patients with longer TpTe (≧72 msec) and shorter TpTe (<72 msec).
Conclusions: The correlation of TpTe with e’ and E/e’ in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e’ predicted outcome, and an elevated E/e’ should be suspected when TpTe is prolonged (> 72 msec). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension.
Journal of Echocardiography
Japanese Society of Echocardiography|Springer nature
The final publication is available at link.springer.com: https://doi.org/10.1007/s12574-019-00421-4
本論文は, 著者Yuko Saitoの学位論文として提出され, 学位審査・授与の対象となっている。
|DOI (Published Version)|
|URL ( Publisher's Version )|
k3266_abstract_review.pdf 249 KB
k3266_summary.pdf 137 KB
|MEXT report number||
Doctor of Medical Science