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ID 114044
Author
Keywords
amide bond cleavage
enrichment
labeling
peptide bond cleavage
target protein
Content Type
Journal Article
Description
Peptides and proteins are involved in almost all biological events. In this review, three chemical biology tools, which were developed for peptide/protein sciences from a viewpoint of peptide/amide bond cleavage, are overviewed. First, study on an artificial amino acid that enables stimulus-responsive functional control of peptides/proteins is briefly described. Two N–S acyl transfer reaction-based tools, one a linker molecule for facile identification of target proteins of bioactive compounds and the other a reagent for selective labeling of proteins of interest, are then discussed.
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
00092363
13475223
NCID
AA00602100
Publisher
The Pharmaceutical Society of Japan
Volume
67
Issue
11
Start Page
1171
End Page
1178
Published Date
2019-11-01
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences