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ID 105936
Title Alternative
動脈硬化患者における不安定プラークの予測因子としての血清ICTP
ICTP and vulnerable plaque
Author
Kato, Shuji Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences
Fujimura, Mitsunori Takamatsu City Hospital
Kuriwaka-Kido, Rika University of Tokushima
Fujinaka, Yuichi University of Tokushima
Iwase, Takashi University of Tokushima KAKEN Search Researchers
Inoue, Daisuke Teikyo University
Keywords
ICTP
vulnerable plaque
necrotic core
matrix metalloproteinase
type I collagen
Content Type
Thesis or Dissertation
Description
Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p<0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients.
Journal Title
Atherosclerosis
ISSN
00219150
NCID
AA00553457
AA11522036
Publisher
Elsevier
Volume
229
Issue
1
Start Page
182
End Page
185
Published Date
2013-04-06
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201311261001.pdf
論文本文 : LID201405271001.pdf
本論文は, 著者Shuji Katoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2649号
Diploma Number
甲医第1175号
Granted Date
2013-09-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences