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ID 114688
Title Alternative
Successful cord blood cell transplantation in a patient with refractory hepatosplenic T-cell lymphoma
臍帯血移植が奏効した肝脾型T細胞リンパ腫
Author
Sogabe, Kimiko Tokushima University
Takahashi, Mamiko Tokushima University
Inoue, Yusuke Tokushima University
Ikegame, Akishige Tokushima University
Keywords
Hepatosplenic T-cell lymphoma
refractory
cord blood transplantation
Content Type
Journal Article
Description
Cord blood for transplant is collected from the umbilical cord and donated cord blood is tested, frozen and stored for future use. Cord blood stem cell transplantation(CBT)do not have to be as closely matched as bone marrow or peripheral blood stem cell transplantations, therefore we are able to perform CBT for refractory patients at optimal timing. Here, we report a 33 years old woman with refractory hepatosplenic T-cell lymphoma(HSTL)who achieved complete response ; CR after unrelated CBT. She complained of fever and abdominal pain, she was diagnosed with HSTL. She was refractory to several chemotherapy regimens, we planned to allogenic transplantation for her. However, she had no HLA-matched sibling donors and we were not able to find favorable unrelated donors from Japan Marrow Donor Program. Therefore, we decided to perform CBT for her. We used fludarabine(180mg/m2), busulfan(12.8mg/kg)and melphalan(80mg/m2) as conditioning regimens and we chose tacrolimus and MMF for graft versus host disease(GVHD) prophylaxis. On day 22 after transplantation, her neutrophil count engrafted, she suffered from acute GVHD(skin, gastrointestinal tract, grade2), she was improved by medical treatment. She achieved CR her disease status maintained over two years after CBT. HSTL is often refractory to chemotherapy, the clinical efficacy of hematopoietic stem cell transplantation may be expected. Our case suggests that CBT may be effective and feasible option for refractory HSTL who has no favorable HLA-matched donors.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
75
Issue
5-6
Start Page
221
End Page
226
Sort Key
221
Published Date
2019-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences