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ID 110034
Title Alternative
Secreted Frizzled-Related Protein-1発現低下は肝内胆管癌において予後不良と関係している
Author
Davaadorj, Mandakhnaran Tokushima University
Teraoku, Hiroki Tokushima University
Yoshikawa, Masato Tokushima University
Keywords
Intrahepatic cholangiocarcinoma
Prognostic factor
SFRP1
β-Catenin
Content Type
Thesis or Dissertation
Description
Aims: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway.
Methods: Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n=30) and negative (n=20). Clinicopathological characteristics were analyzed.
Results: SFRP1 significantly correlated with curability (Cur A, B vs. C, p=0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p=0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer ( p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p=0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p=0.006) survival. In addition, SFRP1 expression negatively correlated to β-catenin expression ( p=0.005).
Conclusions: Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt-β-catenin pathway.
Journal Title
European Journal of Surgical Oncology
ISSN
07487983
NCID
AA10516435
Publisher
Elsevier
Volume
43
Issue
2
Start Page
344
End Page
350
Published Date
2016-12-24
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704121001.pdf
論文本文:LID201704121002.pdf
本論文は, 著者M. Davaadorjの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3008号
Diploma Number
甲医第1312号
Granted Date
2017-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital