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ID 110962
Title Alternative
大腸癌肝転移におけるThrombospondin-1発現の役割とその分子メカニズム
Author
Teraoku, Hiroki University of Tokushima
Yoshikawa, Masato University of Tokushima
Keywords
大腸癌
肝転移
THBS-1
HIF-1
EMT
Thrombospondin-1
colorectal liver metastasis
immunohistochemistry
Content Type
Thesis or Dissertation
Description
Background/Purpose
Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial–mesenchymal transition (EMT), and expression of other relevant molecules.
Methods
Ninety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n=35] and THBS-1 low [n=59]) and tumor growth, Ki-67 labelling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated.
Results
THBS1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS1 expression (3-year survival: 96.7% vs. 65.4%, p<0.01). Multivariate analysis identified THBS1 low expression as an independent prognostic factor (HR=2.82, 95% CI=1.21–7.71, p=0.01). THBS-1 low expression correlated positively with high Ki-67 LI (p<0.05) and inversely with E-cadherin (p<0.05) and hypoxia inducible factor-1α (HIF-1α) expression (p<0.05); THBS-1 expression and MVD were not significantly correlated.
Conclusions
Low THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway.
Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
ISSN
18686974
18686982
NCID
AA12507209
Publisher
Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
Volume
23
Issue
9
Start Page
565
End Page
573
Published Date
2016-07-12
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Hiroki Teraokuの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3118号
Diploma Number
甲医第1353号
Granted Date
2017-10-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital