Yotsumoto, Junko International University of Health and Welfare
Sekizawa, Akihiko Showa University
Inoue, Satomi National Hospital Organization Tokyo Medical Center
Suzumori, Nobuhiro Nagoya City University
Samura, Osamu The Jikei University School of Medicine
Yamada, Takahiro Kyoto University
Miura, Kiyonori Nagasaki University
Masuzaki, Hideaki Nagasaki University
Sawai, Hideaki Hyogo College of Medicine
Murotsuki, Jun Tohoku University
Hamanoue, Haruka Yokohama City University
Kamei, Yoshimasa Saitama Medical University
Endo, Toshiaki Sapporo Medical University
Fukushima, Akimune Iwate Medical University
Katagiri, Yukiko Toho University
Takeshita, Naoki Toho University
Ogawa, Masaki Tokyo Women’s Medical University
Nishizawa, Haruki Fujita Health University
Okamoto, Yoko Osaka Medical Center and Research Institute for Maternal and Child Health
Tairaku, Shinya Kobe University
Kaji, Takashi The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsubara, Keiichi Ehime University
Ogawa, Masanobu National Hospital Organization Kyushu Medical Center
Osada, Hisao Chiba University
Ohba, Takashi Kumamoto University
Kawano, Yukie Oita University
Sasaki, Aiko National Center for Child Health and Development
Sago, Haruhiko National Center for Child Health and Development
Background: Women who receive negative results from non-invasive prenatal genetic testing (NIPT) may find that they later have mixed or ambivalent feelings, for example, feelings of accepting NIPT and regretting undergoing the test. This study aimed to investigate the factors generating ambivalent feelings among women who gave birth after having received negative results from NIPT.
Methods: A questionnaire was sent to women who received a negative NIPT result, and a contents analysis was conducted focusing on ambivalent expressions for those 1562 women who responded the questionnaire. The qualitative data gathered from the questionnaire were analyzed using the N-Vivo software package.
Results: Environmental factors, genetic counseling-related factors, and increased anticipatory anxiety, affected the feeling of ambivalence among pregnant women. Furthermore, pregnant women desired more information regarding the detailed prognosis for individuals with Down syndrome and living with them and/or termination, assuming the possibility that they were positive.
Conclusions: Three major interrelated factors affected the feeling of ambivalence in women. Highlighting and discussing such factors during genetic counseling may resolve some of these ambivalences, thereby enhancing the quality of decisions made by pregnant women.
BMC Pregnancy and Childbirth
Springer Nature|BioMed Central
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