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ID 117383
Title Alternative
Implications of glutathione-S transferase P1 in MAPK signaling
Author
Niitsu, Yoshiro Shonan Kamakura General Hospital|Sapporo Medical University
Keywords
GSTP1
KRAS cancer
BRAF cancer
MAPK signaling
drug resistance
tumor marker
Content Type
Journal Article
Description
Glutathione-S transferase P1 (GSTP1) is one of the glutathione-S transferase isozymes that belong to a family of phase II metabolic isozymes. The unique feature of GSTP1 compared with other GST isozymes is its relatively high expression in malignant tissues. Thus, clinically, GSTP1 serves as a tumor marker and as a refractory factor against certain types of anticancer drugs through its primary function as a detoxifying enzyme. Additionally, recent studies have identified a chaperone activity of GSTP1 involved in the regulation the function of various intracellular proteins, including factors of the growth signaling pathway. In this review, we will first describe the function of GSTP1 and then extend the details onto its role in the mitogen-activated protein kinase signal pathway, referring to the results of our recent study that proposed a novel autocrine signal loop formed by the CRAF/GSTP1 complex in mutated KRAS and BRAF cancers. Finally, the possibilities of new therapeutic approaches for these cancers by targeting this complex will be discussed.
Journal Title
Proceedings of the Japan Academy, Series B, Physical and Biological Sciences
ISSN
03862208
13492896
NCID
AA00785485
Publisher
The Japan Academy
Volume
98
Issue
2
Start Page
72
End Page
86
Published Date
2022-02-10
Rights
Published under the terms of the CC BY-NC license https://creativecommons.org/licenses/by-nc/4.0/.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences