ID 110403
Title Transcription
テンイソウ デ ホルモン ジュヨウタイ ノ ヘンイ オ ミトメタ ニュウガン ノ 1レイ
Title Alternative
A case of breast cancer with conversion of estrogen and progesterone receptor expresson in metastatic lesion
Author
Harino, Yukari Division of Thyroid and Breast Disease, Taoka Hospital
Okitsu, Natsu Division of Thyroid and Breast Disease, Taoka Hospital
Miki, Hitoshi Division of Thyroid and Breast Disease, Taoka Hospital
Keywords
breast cancer
hormone receptor
receptor conversion
metastatic lesion
Content Type
Journal Article
Description
A 44 year old woman visited the hospital with complaint of the right breast tumor which she left for two years. She presented with a large mass of8.5cm in diameter with skin invasion, right axillar lymph nodes, multiple liver, and bone metastases. Core needle biopsy of the main tumor revealed an invasive ductal carcinoma(scirrhous carcinoma)with nuclear grade 2 with ER(+),PgR(+), HER2(-). The patient was treated with hormone therapy for three and a half year.The extensive mediastinum lymph nodes metastasis and multiple lung metastasis and a new tumor in the right thyroid lobe were appeared. The liver metastasis also increased in size and number.The therapy switched to chemotherapy with paclitaxel. Although the reductive effect was appeared in the breast mass, lung metastasis and liver metastasis, the thyroid and mediastinal lymph node metastases increased in size aggressively. The cytology of needle biopsy specimen from the thyroid tumor was consistent with breast cancer metastasis. Histopathology of the biopsy specimens from the mediastinal lymph node and the liver metastases also consist with breast cancer metastases, but ER and PgR receptor status converted to negative in mediastinal lymph nodes.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
72
Issue
5-6
Start Page
199
End Page
204
Sort Key
199
Published Date
2016-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences