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ID 114525
Title Alternative
統合失調症患者の社会機能と認知機能の関連
Social and cognitive functions in schizophrenia
Author
Takeda, Tomoya Tokushima University
Tanaka, Tsunehiko Niigata University
Kaneda, Yasuhiro Iwaki Clinic
Keywords
schizophrenia
social function
negative symptom
cognitive function
speed of processing
Content Type
Thesis or Dissertation
Description
Purpose: The purpose of the present study was to examine clinical factors related to social function in people with schizophrenia.
Patients and methods: The participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale.
Results: Neither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score.
Conclusion: These results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.
Journal Title
Neuropsychiatric Disease and Treatment
ISSN
11766328
Publisher
Dove Medical Press
Volume
14
Start Page
2215
End Page
2224
Published Date
2018-08-30
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takeo Tominagaの学位論文として提出され,学位審査・授与の対象となっている
Rights
© 2018 Tominaga et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
乙第2111号
Diploma Number
乙医第1759号
Granted Date
2020-03-05
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
Integrated Arts and Sciences
University Hospital
Health Service and Counseling Center
Academic Support Office for Students with Special Needs