ID | 106365 |
Author |
Kashiwagi, Masayuki
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Ishigami, Akiko
Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
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Hara, Kenji
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Matsusue, Aya
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Waters, Brian
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Takayama, Mio
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Tokunaga, Itsuo
Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
Nishimura, Akiyoshi
Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
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Kubo, Shin-ichi
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
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Keywords | coma blister
sweat gland degeneration
apoptosis
intoxication
forensic autopsy cases
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Content Type |
Journal Article
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Description | The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 60
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Issue | 3-4
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Start Page | 256
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End Page | 261
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Sort Key | 256
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Published Date | 2013-08
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EDB ID | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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