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ID 118536
Title Alternative
Sudden death after COVID-19 vaccination
Author
Kurata, Hiromitsu Tokushima University|Nakazu-Yagi Hospital
Umemoto, Hitomi Tokushima University
Iseki, Hirofumi Tokushima University|Nakazu-Yagi Hospital
Keywords
Systemic inflammation
Myopericarditis
COVID-19
Vaccines
Sudden death
Autopsy
Content Type
Journal Article
Description
A 14-year-old Japanese girl died unexpectedly 2 days after receiving the third dose of the BNT1262b2 mRNA COVID-19 vaccine. Autopsy findings showed congestive edema of the lungs, T-cell lymphocytic and macrophage infiltration in the lungs, pericardium, and myocardium of the left atria and left ventricle, liver, kidneys, stomach, duodenum, bladder, and diaphragm. Since there was no preceding infection, allergy, or drug toxicity exposure, the patient was diagnosed with post-vaccination pneumonia, myopericarditis, hepatitis, nephritis, gastroenteritis, cystitis, and myositis. Although neither type of inflammation is fatal by itself, arrhythmia is reported to be the most common cause of death in patients with atrial myopericarditis. In the present case, arrhythmia of atrial origin was assumed as the cause of cardiac failure and death. In sudden post-vaccination deaths, aggressive autopsy systemic search and histological examination involving extensive sectioning of the heart, including the atrium, are indispensable.
Journal Title
Legal Medicine
ISSN
18734162
13446223
NCID
AA11327981
AA11644485
Publisher
Elsevier
Volume
63
Start Page
102244
Published Date
2023-03-20
Rights
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
https://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Medical Sciences