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ID 114197
Title Alternative
TGs and CV Events
Author
Kajikawa, Masato Hiroshima University
Maruhashi, Tatsuya Hiroshima University
Kishimoto, Shinji Hiroshima University
Matsui, Shogo Hiroshima University
Hashimoto, Haruki Hiroshima University
Takaeko, Yuji Hiroshima University
Mohamad Yusoff, Farina Hiroshima University
Kihara, Yasuki Hiroshima University
Chayama, Kazuaki Hiroshima University
Goto, Chikara Hiroshima International University
Noma, Kensuke Hiroshima University
Nakashima, Ayumu Hiroshima University
Tomiyama, Hirofumi Tokyo Medical University
Takase, Bonpei National Defense Medical College Research Institute
Kohro, Takahide Jichi Medical University
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Koba, Shinji Showa University
Watanabe, Kentaro Yamagata University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Ikeda, Hisao Teikyo University
Yamashina, Akira Tokyo Medical University
Higashi, Yukihito Hiroshima University
Keywords
Atherosclerosis
Cardiovascular events
Triglycerides
Content Type
Journal Article
Description
Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy.
Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100–149 mg/dL), borderline hypertriglyceridemia (150–199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL.
Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.
Journal Title
Circulation Journal
ISSN
13469843
13474820
NCID
AA11591968
Publisher
The Japanese Circulation Society
Volume
83
Issue
5
Start Page
1064
End Page
1071
Published Date
2019-04-25
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences