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ID 111437
Title Alternative
骨髄由来線維細胞は肺がん細胞のがん幹細胞様特性を増強する
Author
Nakano, Mayuri Tokushima University
Mitsuhashi, Atsushi Tokushima University
Keywords
Lung cancer
Cancer stem cell
Fibrocyte
Tumor microenvironment
AKT pathway
Content Type
Thesis or Dissertation
Description
Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14þ monocytes and have features of both macrophages and fibroblasts. Accumulating evidence has suggested that stromal fibrocytes might promote cancer progression. However, the role of fibrocytes in the CSC niches has not been revealed. We herein report that human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.
Journal Title
Cancer Letters
ISSN
03043835
NCID
AA00598513
AA1152274X
Publisher
Elsevier
Volume
421
Start Page
17
End Page
27
Published Date
2018-02-12
Remark
内容要旨・審査要旨・論文本文の公開
Rights
© 2018 Published by Elsevier B.V.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3131号
Diploma Number
甲医第1365号
Granted Date
2018-03-20
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital