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ID 113349
Title Alternative
メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する
EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME
Author
Watanabe, Syunsuke Tokushima University
Baba, Hayato Tokushima University
Morimoto, Yuki Tokushima University
Keywords
animal model
beta cell failure
coffee intake
hepatocellular carcinoma
nonalcoholic steatohepatitis
Content Type
Thesis or Dissertation
Description
Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.
Methods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.
Results: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.
Conclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
Journal Title
Metabolic Syndrome and Related Disorders
ISSN
15404196
15578518
NCID
AA11853678
AA12814809
Publisher
Mary Ann Liebert, Inc.
Volume
15
Issue
4
Start Page
170
End Page
177
Published Date
2017-05-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Syunsuke Watanabeの学位論文として提出され,学位審査・授与の対象となっている。
Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/met.2016.0114
Rights
© 2017, Mary Ann Liebert, Inc.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3265号
Diploma Number
甲医第1414号
Granted Date
2019-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital