Total for the last 12 months
number of access : ?
number of downloads : ?
ID 111271
Title Alternative
浸潤性子宮頸癌における血管内皮増殖因子の発現と微小血管密度の重要性について
Author
Furumoto, Hiroyuki The University of Tokushima|Tokushima Red Cross Hospital KAKEN Search Researchers
Keywords
cervical cancer
vascular endothelial growth factor
microvessel density
bevacizumab
angiogenesis
Content Type
Thesis or Dissertation
Description
To determine whether vascular endothelial growth factor (VEGF) expression and microvessel density are predictive of prognosis in cases of invasive cervical cancer, correlations among VEGF expression, microvessel density, and clinicopathological parameters were identified. VEGF expression was evaluated in 50 cervical cancer samples by immunohistochemical staining. Microvessel density was assessed by immunostaining for CD31-positive endothelial cells in the most vascularized areas of tumors. VEGF expression and microvessel density were significantly higher in adenocarcinomas than in squamous cell carcinomas. However, in cases of adenocarcinoma, no significant correlations were found among VEGF expression, microvessel density, and clinicopathological parameters. In contrast, for squamous cell carcinomas, microvessel density was significantly higher in cases at an advanced stage and in those with several other poor prognostic factors. The finding that cervical adenocarcinomas exhibited greater VEGF expression and microvessel density than squamous cell carcinomas may explain the poorer prognosis of adenocarcinoma compared with squamous cell carcinoma. Moreover, microvessel density in squamous cell carcinomas was significantly correlated with poor prognostic factors. Therefore, there is possibility that bevacizumab, a humanized monoclonal antibody against VEGF-A, may be useful in the initial treatment targeting angiogenesis for early-stage cervical cancer.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
154
End Page
160
Sort Key
154
Published Date
2015-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505211003.pdf
論文本文 : LID201505211004.pdf
本論文は,著者Yasuyo Saijoの学位論文として提出され,学位審査・授与の対象となっている。
西條康代の姓「西」の正確な漢字については審査要旨をご参照ください。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2800号
Diploma Number
甲医第1242号
Granted Date
2015-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences