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ID 109704
Title Alternative
成長期における咀嚼性刺激の減少が下顎骨の性状に及ぼす影響
Effects of Decreased Loading on the Mandible
Author
Ruijven, Leo J. van University of Amsterdam and VU University Amsterdam
Langenbach, Geerling E. J. University of Amsterdam and VU University Amsterdam
Keywords
muscle activity
loading stimulus
bone remodeling
mineralization
Content Type
Thesis or Dissertation
Description
Background
Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass.
Methods and Findings
Ten 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05).
Conclusion
Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
10
Issue
6
Start Page
e0129290
Published Date
2015-06-10
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201606141001.pdf
審査要旨 : LID201606141002.pdf
論文本文 : LID201606141003.pdf
本論文は, 著者Natsuko Hichijoの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
Copyright: © 2015 Hichijo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2939号
Diploma Number
甲口第404号
Granted Date
2016-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
University Hospital
Oral Sciences