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ID 113942
Author
Matsumoto, Tomoya Tokushima University
Toguchi, Munehisa Tokushima University
Keywords
Horner-Wadsworth-Emmons reagents
Still-Gennari reagent
phosphorus
Garegg-Samuelsson reaction conditions
2,2,2-trifluoroethanol
Content Type
Journal Article
Description
A facile two-step synthesis of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate (Still–Gennari reagent) has been developed by exploiting Garegg–Samuelsson reaction conditions. Starting from trimethyl phosphonoacetate, Still–Gennari reagent was prepared in 94% yield via methyl 2-{bis[(trimethylsilyl)oxy]phosphoryl}acetate intermediate. This synthetic procedure was also used to prepare some kinds of Horner–Wadsworth–Emmons reagents and related compounds.
Journal Title
Synlett
ISSN
09365214
14372096
NCID
AA10731110
Publisher
Georg Thieme Verlag Stuttgart
Volume
29
Issue
11
Start Page
1461
End Page
1464
Published Date
2018-04-13
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences