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ID 110102
Title Alternative
高い変形能を示すチタン繊維編物内部への骨成長
Author
Henmi, Yoko Tokushima University
Jimbo, Ryo Malmö University
Jinno, Yohei Malmö University
Keywords
biocompatible materials
bone formation
bone substitutes
elastic modulus
histological techniques
titanium
Content Type
Thesis or Dissertation
Description
Objectives: The objective of this study is to develop a Ti fibre knit block without sintering, and to evaluate its deformability and new bone formation in vivo.
Material and Methods: A Ti fibre with a diameter of 150 μm was knitted to fabricate a Ti mesh tube. The mesh tube was compressed in a metal mould to fabricate porous Ti fibre knit blocks with three different porosities of 88%, 69%, and 50%. The elastic modulus and deformability were evaluated using a compression test. The knit block was implanted into bone defects of a rabbit’s hind limb, and new bone formation was evaluated using micro computed tomography (micro-CT) analysis and histological analysis.
Results: The knit blocks with 88% porosity showed excellent deformability, indicating potential appropriateness for bone defect filling. Although the porosities of the knit block were different, they indicated similar elastic modulus smaller than 1 GPa. The elastic modulus after deformation increased linearly as the applied compression stress increased. The micro-CT analysis indicated that in the block with 50% porosity new bone filled nearly all of the pore volume four weeks after implantation. In contrast, in the block with 88% porosity, new bone filled less than half of the pore volume even 12 weeks after implantation. The histological analysis also indicated new bone formation in the block.
Conclusions: The titanium fibre knit block with high porosity is potentially appropriate for bone defect filling, indicating good bone ingrowth after porosity reduction with applied compression.
Journal Title
Journal of Oral & Maxillofacial Research
ISSN
2029283X
Publisher
Journal of Oral & Maxillofacial Research
Volume
7
Issue
4
Start Page
e2
Published Date
2016-12-28
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨:LID201704261011.pdf
審査要旨:LID201704261012.pdf
論文本文:LID201704261013.pdf
本論文は,著者Yoko Henmiの学位論文として提出され,学位審査・授与の対象となっている。
Rights
Copyright © Henmi Y, Naito Y, Jimbo R, Jinno Y, Sekine K, Hamada K. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 28 December 2016.
This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License(https://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3081号
Diploma Number
甲口第424号
Granted Date
2017-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
University Hospital
Oral Sciences