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ID 111401
Title Alternative
クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
Author
Indalao, Irene L. Tokushima University
Sawabuchi, Takako Tokushima University
Mizuno, Keiko Tokushima University
Sakai, Satoko Tokushima University
Kimoto, Takashi Tokushima University
Kim, Hyejin Tokushima University
Keywords
Matrix metalloproteinase-9
Macrolide
Clarithromycin
Influenza A virus
Multiple organ failure
Evans’ blue extravasation
Influenza A virus infection
Content Type
Thesis or Dissertation
Description
The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.
Journal Title
Comparative Immunology, Microbiology and Infectious Diseases
ISSN
01479571
NCID
AA11644419
AA00612035
Publisher
Elsevier
Volume
56
Start Page
6
End Page
13
Published Date
2017-11-23
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Etsuhisa Takahashiの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3122号
Diploma Number
甲医第1356号
Granted Date
2018-01-25
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Institute of Advanced Medical Sciences