ID | 116455 |
Title Alternative | β5t shapes CD8 T cells without negative selection
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Author |
Ohigashi, Izumi
University of Tokushima
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Frantzeskakis, Melina
National Institutes of Health
Jacques, Alison
National Institutes of Health
Fujimori, Sayumi
University of Tokushima
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Yamashita, Fusano
University of Tokushima
Ishimaru, Naozumi
Tokushima University
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Yin, Da
National Institutes of Health
Cam, Margaret
National Institutes of Health
Kelly, Michael C.
National Institutes of Health
Awasthi, Parirokh
National Institutes of Health
Takahama, Yousuke
National Institutes of Health
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Content Type |
Journal Article
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Description | The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.
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Journal Title |
Journal of Experimental Medicine
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ISSN | 00221007
15409538
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NCID | AA00697559
AA12119243
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Publisher | Rockefeller University Press
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Volume | 218
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Issue | 4
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Start Page | e20201904
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Published Date | 2021-02-08
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Rights | This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Institute of Advanced Medical Sciences
Oral Sciences
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