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ID 114971
Author
Kikuta, Satomi Tohoku University|Japan Science and Technology Agency|Japan Society for the Promotion of Science
Nakamura, Yukiyo Tokushima University
Yamamura, Yukio Tokushima University
Tamura, Atsushi Tohoku University|Japan Science and Technology Agency|Northwestern University
Homma, Noriyasu Tohoku University
Yanagawa, Yuchio Japan Science and Technology Agency|Gunma University
Tamura, Hajime Tohoku University
Osanai, Makoto Tohoku University|Japan Science and Technology Agency
Content Type
Journal Article
Description
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
5
Start Page
12800
Published Date
2015-08-10
Rights
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences