ID 105999
Author
Mitamura, Yoshinori Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Mitamura-Aizawa, Sayaka Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School
Nagasawa, Toshihiko Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School
Katome, Takashi Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Eguchi, Hiroshi Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Naito, Takeshi Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
diagnostic imaging
fundus autofluorescence
optical coherence tomography
retinal photoreceptor cell
retinitis pigmentosa
Content Type
Journal Article
Description
Retinitis pigmentosa (RP) is a progressive inherited retinal disease, and patients with RP have reduced visual function caused by a degeneration of the photoreceptors and retinal pigment epithelium (RPE). At the end stage of RP, the degeneration of the photoreceptors in the fovea reduces central vision, and RP is one of the main causes of acquired blindness in developed countries. Therefore, morphological and functional assessments of the photoreceptors in the macula area can be useful in estimating the residual retinal function in RP patients. Optical coherence tomography (OCT) is a wellestablished method of examining the retinal architecture in situ. The photoreceptor inner/outer segment (IS/OS) junction is observed as a distinct, highly reflective line by OCT. The presence of the IS/OS junction in the OCT images is essential for normal visual function. Fundus autofluorescence (FAF) results from the accumulation of lipofuscin in the RPE cells and has been used to investigate RPE and retinal function. More than one-half of RP patients have an abnormally high density parafoveal FAF ring (AF ring). The AF ring represents the border between functional and dysfunctional retina. In this review, we shall summarize recent progress on diagnostic imaging in eyes with RP.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
59
Issue
1-2
Start Page
1
End Page
11
Sort Key
1
Published Date
2012-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital
International Center