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ID 116667
Author
Morioka, Masakazu University of Fukui
Takamura, Yoshihiro University of Fukui
Nagai, Kazuki Gunma University
Yoshida, Shigeo Kurume University
Mori, Junya Sapporo City General Hospital
Takeuchi, Masaru National Defense Medical College
Sawada, Tomoko Shiga University of Medical Science
Sone, Kumiko Tokyo Medical University
Fukuyama, Hisashi Hyogo College of Medicine
Kusuhara, Sentaro Kobe University
Yasukawa, Tsutomu Nagoya City University
Murakami, Tomoya University of Tsukuba
Tabuchi, Hitoshi Saneikai Tsukazaki Hospital
Nagasato, Daisuke Saneikai Tsukazaki Hospital
Hirano, Takao Shinshu University
Ueda, Tetsuo Nara Medical University
Jujo, Tatsuya St. Marianna University
Sasajima, Hirofumi Aichi Medical University
Ishikawa, Kunihiro Tokyo Women’s Medical University
Inatani, Masaru University of Fukui
Content Type
Journal Article
Description
Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test, p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
10
Start Page
22122
Published Date
2020-12-17
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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language
eng
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departments
Medical Sciences