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ID 114642
Title Alternative
UVA-LED照射装置を用いた、基質特異性拡張型βラクタマーゼ産生大腸菌の殺菌
Inactivation of ESBL-E. coli
Author
Ulfa, Maria Tokushima University
Sato, Masami Tokushima University
Fukushima, Shiho Tokushima University
Kido, Junko Tokushima University
Keywords
extended-spectrum β-lactamase (ESBL)
ESBL-E. coli
E. coli
UVA-LED irradiation
Content Type
Thesis or Dissertation
Description
The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly and spreading worldwide, particularly in Asia, compared to other regions. In the last ten years, in our hospital, in particular, there has been a < 30% increase. To prevent the spread of ESBL in hospitals and the community, the ultraviolet (UV) A-light-emitting diode (LED) irradiation device was used to inactivate ESBL-E. coli in human livestock and the environment. ESBL-E. coli and E. coli bacterial samples were collected from patients at Tokushima University Hospital (Tokushima City, Japan). The UVA-LED irradiation system had 365 nm single wavelength, and the current of the circuit was set to 0.23 or 0.50 A consistently. Results demonstrated that UVA-LED was useful for the inactivation of ESBL-E. coli and E. coli. The minimum energy dosage required to inactivate ESBL-E. coli and E. coli was 40.76 J/cm2 (45 min) in the first type of UVA-LED and 38.85 J/cm2 (5 min) in the second type. There were no significant differences between ESBL-E. coli and E. coli. The inactivation of ESBL-E. coli was dependent on energy. These findings suggest that UVA-LED with 365 nm single wavelength could be useful for surface decontamination in healthcare facilities.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
67
Issue
1-2
Start Page
163
End Page
169
Sort Key
163
Published Date
2020-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Maria Ulfaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3410号
Diploma Number
甲栄第271号
Granted Date
2020-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences
Science and Technology